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    • Alternative Depression Treatments – Deep TMS & Spravato
    • Spravato Treatment – FDA-Approved Esketamine for Depression
    • TMS Treatment – Deep Transcranial Magnetic Stimulation Therapy
    • Women’s Depression Treatment
    • Medication Management
    • Paid Mental Health Leave Support
    • Student Mental Health
    • LGBTQ+ Mental Health
    • Mental Health Insurance
    • Step Down Care
    • Deprescribing Services
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    • Andrew Wenner, PMHNP
    • Madison Walter, PMHNP-BC
    • Elinor O’Buckley, MSN, PMHNP
    • Sarah McLaughlin, MSN, PMHNP
    • Frani Rhodes, MSN, WHNP-BC
    • Ross Van Allen, DNP
    • Roderick O’Brien, MD
    • Michelle Godwin
    • Tori Kause
    • Kayla Sharpe, MSN, APRN, PMHNP-BC
    • Ben Egbers, DNP, APN, PMHNP-BC
    • Tiffany Lawrence, PMHNP-BC
    • Ebony Villarreal, PA-C
    • Marina Pitsilos, MSN, PMHNP-BC
  • Locations
    • Denver
    • Boulder
    • Westminster
    • Denver Tech Center
    • Telehealth
  • Patient Center
    • New Patient Welcome
    • Best Mind Patients
    • Patient Feedback
    • Contact Us
  • The 266 Project
    • Directory of Mental Health Services and Providers
    • Events
    • 266K Swag
    • Premier Partners
  • About Us
    • Patient Stories
    • Patient Testimonials
    • Press
    • Blog
    • The Brave Podcast
    • Careers
  • Referrals

December 22, 2025

Why Do Antidepressants Stop Working During Perimenopause?

Why Do Antidepressants Stop Working During Perimenopause?

Depression in WomenBy Axis Integrated Mental HealthDecember 22, 2025

If you are in your 40s or early 50s and feel like your antidepressant suddenly stopped working, you are not alone. Many women reach a point where a medication that once helped with mood, anxiety, or irritability seems less effective, even if nothing else has changed. This can be confusing and discouraging, especially if you…

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