Mary Chamberlain is a board-certified Physician Assistant with a Certificate of Added Qualifications (CAQ) in Psychiatry, specializing in treatment-resistant depression through advanced modalities including TMS therapy and Spravato ketamine therapy treatment. With over six years of experience spanning inpatient crisis stabilization, community mental health, and integrative outpatient psychiatry, Mary brings a uniquely comprehensive perspective to mental health care in Greenwood Village. She combines evidence-based psychiatric medication management with cutting-edge interventional treatments, helping patients who haven’t found relief through traditional approaches finally experience meaningful recovery.

Why Physical Movement Matters in Psychiatric Treatment (And Why Most Providers Don’t Talk About It)

When Mary evaluates patients for treatment-resistant depression, she asks a question many psychiatrists skip: “How much are you moving your body?” This isn’t small talk-it’s clinical assessment grounded in neuroscience. While other integrative psychiatry providers in Colorado discuss nutrition and sleep hygiene, Mary specifically addresses the synaptic mechanisms through which regular physical activity potentiates psychiatric treatment response.

Here’s what makes this clinically significant: patients receiving TMS therapy or Spravato treatment who maintain consistent physical activity demonstrate faster symptom improvement and more durable outcomes. Mary doesn’t prescribe generic “exercise more” advice. She collaborates with patients to identify realistic movement patterns that align with their current functioning level-whether that’s a 10-minute walk or returning to a previous fitness routine. This practical approach to integrative psychiatry recognizes that depression often makes movement feel impossible, so treatment must address the neurobiological barriers first, then leverage physical activity as response accelerates.

This perspective comes from Mary’s clinical observation across multiple treatment settings: patients who integrate movement alongside psychiatric interventions consistently report better outcomes. She’s witnessed this pattern in inpatient units, community mental health centers, and outpatient practices. It’s not about wellness culture-it’s about optimizing treatment response through multimodal intervention.

Evidence-Based Treatment for Depression That Hasn’t Responded to Medication

Mary specializes in integrative psychiatry for adults 18 and older who haven’t achieved adequate response with traditional antidepressant medications. Her clinical approach combines psychopharmacology expertise with advanced interventional treatments including Deep TMS (using both Apollo and Brainsway systems) and Spravato (esketamine) therapy.

What distinguishes Mary’s practice is her extensive experience across the full spectrum of psychiatric acuity. She’s treated acute inpatient crises, managed complex medication regimens in community mental health settings, and guided patients through sophisticated outpatient protocols. This breadth means she understands not just how treatments work in ideal conditions, but how they perform for real patients with complicated histories, multiple diagnoses, and previous treatment failures.

Her training includes specialized certification in TMS mapping and treatment procedures for both Apollo and Brainsway devices-the two leading Deep TMS systems. She’s also completed advanced psychopharmacology training through Postpartum Support International and cognitive-behavioral therapy training at the Beck Institute. This combination allows her to integrate multiple therapeutic approaches based on each patient’s specific presentation rather than defaulting to a single treatment philosophy.

Mary’s approach to medication management emphasizes precision over proliferation. Rather than continually adding medications, she conducts thorough diagnostic assessment to understand why previous treatments failed, then develops targeted interventions that address the underlying mechanisms. For patients with treatment-resistant depression, this often means transitioning to TMS therapy or Spravato treatment rather than trial-and-error with additional antidepressants.

Who Benefits from Mary’s Integrative Approach

Mary works with adults experiencing:

• Treatment-resistant depression: Patients who haven’t responded adequately to multiple antidepressant trials and are candidates for TMS therapy or Spravato treatment
• Complex diagnostic presentations: Individuals with co-occurring anxiety disorders, PTSD, or other conditions requiring nuanced medication management
• Postpartum and perinatal mood disorders: Specialized training through Postpartum Support International informs Mary’s work with this population
• Chronic depression affecting daily functioning: Patients struggling with work performance, relationship maintenance, or self-care due to persistent depressive symptoms

Her practice particularly serves patients in the Greenwood Village and Denver Tech Center area who need a provider comfortable with both traditional psychiatry and advanced interventional treatments. Many of her patients have worked with multiple providers, tried numerous medications, and felt frustrated by limited improvement. Mary’s experience across inpatient, community, and outpatient settings means she understands the full trajectory of psychiatric illness and recovery.

Clinical Background & Training

Mary earned her Bachelor’s degree in Biomedical Sciences with a minor in Psychology from Auburn University, then completed her Master of Science in Physician Assistant Studies at the University of Alabama at Birmingham. She began her psychiatric career at Alabama Psychiatry, where she provided inpatient consultation services at Brookwood Hospital and outpatient care for specialized populations including pregnancy and postpartum patients.

After relocating to Colorado in 2022, Mary worked at WellPower (formerly The Mental Health Center of Denver), gaining extensive experience in community mental health and collaborative care models. She joined BestMind in January 2024, where she provides integrative psychiatric services including TMS and Spravato treatment.

Mary holds her Colorado Physician Assistant License, NCCPA certification, Certificate of Added Qualifications (CAQ) in Psychiatry, and DEA licensure. She maintains proficiency in multiple electronic health record systems and serves as a preceptor for physician assistant students, training the next generation of psychiatric providers.

Why Mary Chose Psychiatric Medicine

Mary discovered her calling during her physician assistant clinical rotations in behavioral health services. What struck her wasn’t just the complexity of psychiatric illness-it was witnessing patients transform when they finally received effective treatment. She’s remained in mental health ever since, driven by the profound impact psychiatric intervention can have on patients who’ve suffered for years.

“Before working directly with integrative mental health techniques like Spravato and TMS, I was skeptical about their effectiveness,” Mary reflects. “Now that I’ve seen my patients’ recovery firsthand, I can’t imagine not utilizing these tools for treatment-resistant depression.” This evolution from skepticism to advocacy reflects her evidence-based approach: she trusts what she’s witnessed clinically, not just what sounds theoretically promising.

Outside of clinical practice, Mary is an avid hiker and Dungeons & Dragons player. Patients frequently describe her as “thorough”-a reflection of her highly organized approach to psychiatric assessment and treatment planning. Her friends note her skill at bringing people together, a quality that translates to her collaborative work with treatment teams including therapists, case managers, and other healthcare providers.

Start with a Free Consultation

Mary is currently accepting new patients at Axis Integrated Mental Health in Greenwood Village or telehealth across Colorado.

You can also schedule your first appointment with Mary Chamberlain by booking online.

If you’re not ready to book an appointment yet with her, we offer a free consultation to discuss your treatment goals, review your insurance benefits, and provide a general guideline for costs. This no-obligation conversation allows you to meet with an Axis Integated Mental Health team member, understand our approach, and determine whether integrative psychiatry is right for you.

During your consultation, we’ll review your previous treatment history, discuss options including TMS therapy and Spravato treatment, and can provide an estimate of costs based on your insurance. Our insurance mental health benefits guide can also help you understand your out-of-pocket costs before committing to care.

Axis Integrated Mental Health serves Greenwood Village, Denver Tech Center, and surrounding Colorado communities or across Colorado via telehealth.