What to Do After Ketamine Treatment to Maximize Recovery

Why the Post-Treatment Window Is So Important

Ketamine's antidepressant effects don't stop when your appointment ends. In fact, the hours and days following treatment are when your brain is most primed for healing. Ketamine therapy rapidly promotes neuroplasticity—your brain's ability to form new connections—especially within the first 2 to 12 hours after treatment. During this window, what you do can significantly impact your recovery.

What Ketamine Does in the Brain—and Why It’s Unique

Unlike SSRIs that slowly increase serotonin over weeks, ketamine targets the glutamate system, rapidly improving mood by stimulating NMDA receptors. This activation releases brain-derived neurotrophic factor (BDNF), which supports new synapse formation and increases neuroplasticity. Studies show dendritic spine growth begins within hours of treatment, supporting long-term mood regulation. Learn about the science on how neuroplasticity improves mental health and how ketamine, psilocybins and TMS reshape neuroplasticity.

The 2 Most Common Myths About Ketamine Debunked

Myth #1: IV ketamine is better than Spravato. Fact: Research from Yale and Cambridge shows that Spravato (nasal esketamine) and IV ketamine are similarly effective. IV may require fewer treatments but comes with higher out-of-pocket costs. 

Myth #2: You must dissociate for ketamine to work. Fact: Dissociation is a side effect, not a measure of success. Relief can occur with or without this experience.

For more research on the difference between esketamine, read our following articles:

• Esketamine vs Ketamine. Are They the Same Thing?
• Spravato vs. Ketamine Infusions: Which Is Better for Treatment-Resistant Depression?
• What is Spravato and Why is It So Effective for Treating Depression?

Boosting Neuroplasticity After Ketamine

To make the most of the neuroplasticity window, engage in brain-stimulating and calming activities:

• Mindfulness meditation: Enhances emotional regulation and self-awareness
• Aerobic exercise: Increases BDNF and boosts mood
• Cognitive stimulation: Reading, puzzles, journaling, or learning a new skill helps reinforce positive pathways

Post-Ketamine Therapy Do’s

• Schedule therapy sessions: Integration is key. Talk therapy helps you process insights and build new emotional habits.
• Prioritize self-care: Sleep, hydration, and nutritional psychiatry support brain and body recovery.
• Meditate and practice mindfulness: Deep breathing or guided meditation improves neural rewiring.
• Stay physically active: Movement can heal PTSD and other mental health conditions. Even a walk can support endorphin release and help sustain your progress.
• Seek social support: Connect with friends, support groups, or explore social prescribing programs.
• Schedule follow-up appointments: See your provider regularly to track progress and adjust your treatment plan.
• Consider TMS therapy: Transcranial Magnetic Stimulation can complement ketamine's effects and provide long-term benefits.

Post-Ketamine Therapy Don’ts

• Do not drive: Your motor skills may be impaired even if you feel fine. Always arrange transportation.
• Avoid heavy meals immediately after: Start with something light to avoid nausea.
• Limit news consumption: Sensational or distressing news can negatively affect your mood. "Doomscrollling" can make your anxiety worse.
• Take a break from social media: Reduce stimulation and comparison triggers. Focus on your internal healing process.

Post-Ketamine Integration: Why Self-Reflection Matters

Journaling or reflecting on your ketamine experience helps consolidate insights. Ask yourself: What did I feel? What patterns surfaced? How can I apply these realizations?

Integration turns the neuroplastic window into long-term change.

Want to Know if You Qualify for Insurance-Covered Ketamine Therapy in Denver, Westminster, or Boulder? 

Wondering if Spravato® could be the breakthrough you’ve been searching for? Take this quick quiz to find out if you may be a candidate.

• Important note: Only a licensed psychiatric provider can determine eligibility. This quiz is meant to help you understand if it’s worth scheduling an evaluation.

Conclusion

Knowing what to do after ketamine treatment is critical for long-lasting improvement. Take advantage of neuroplasticity with the right support, therapy, and lifestyle changes. Whether you received Spravato or IV ketamine, Axis Integrated Mental Health is here to support you every step of the way.

Recovery from depression is not a one-time event. Ketamine opens the door, but continued support helps you walk through it. Your Axis provider can help personalize a plan for maintenance therapy, therapy referrals, or exploring TMS.

Ready to Take the Next Step?

Axis Integrated Mental Health offers personalized consultations to help you choose the best path forward. Call us at (720) 400-7025 or book an appointment online to start your journey toward better mental health.

People Also Ask

1. How long should I wait to resume normal activities after ketamine treatment?
2. What should I do if I don’t feel better right away after ketamine?
3. Can I combine ketamine with other treatments like TMS or therapy?
4. What foods or supplements support brain recovery post-ketamine?
5. Is it normal to feel emotional or tired the day after treatment?